Tyr667
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Home > Phosphorylation Site Page: > Tyr667  -  Siglec-10 (human)

Site Information
ESQEELHyATLNFPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450087
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 , 4 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , leukemia ( 2 ) , acute myelogenous leukemia ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 4 ) , glial-brain ( 1 ) , Jurkat (T lymphocyte) ( 4 ) , UT-7 (myeloid) ( 2 ) , yeast cell ( 3 )

Upstream Regulation
Putative in vivo kinases:
Fyn (human) ( 3 )
Kinases, in vitro:
ITK (human) ( 4 ) , JAK3 (human) ( 4 ) , Lck (human) ( 4 )

Downstream Regulation
Effects of modification on Siglec-10:
molecular association, regulation ( 3 , 4 )
Induce interaction with:
SHP-1 (human) ( 3 , 4 ) , SHP-2 (human) ( 4 )

References 

1

Johnson H, White FM (2014) Quantitative analysis of signaling networks across differentially embedded tumors highlights interpatient heterogeneity in human glioblastoma. J Proteome Res 13, 4581-93
24927040   Curated Info

2

Gu T (2005) CST Curation Set: 758; Year: 2005; Biosample/Treatment: cell line, UT-7/elastase; Disease: acute myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J (2002) Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. Biochem Biophys Res Commun 296, 355-62
12163025   Curated Info

4

Whitney G, et al. (2001) A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33. Eur J Biochem 268, 6083-96
11733002   Curated Info