Tyr597
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Home > Phosphorylation Site Page: > Tyr597  -  Siglec-10 (human)

Site Information
RHstILDyINVVPTA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450086

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 5 )
Disease tissue studied:
lymphoma ( 1 ) , Burkitt's lymphoma ( 1 ) , melanoma skin cancer ( 2 , 4 )
Relevant cell line - cell type - tissue:
BJAB (B lymphocyte) ( 1 ) , COS (fibroblast) ( 5 ) , Jurkat (T lymphocyte) ( 3 , 5 ) , skin ( 2 , 4 )

Upstream Regulation
Kinases, in vitro:
ITK (human) ( 5 ) , JAK3 (human) ( 5 ) , Lck (human) ( 5 )

References 

1

Rolland D, et al. (2014) Global phosphoproteomic profiling reveals distinct signatures in B-cell non-Hodgkin lymphomas. Am J Pathol 184, 1331-42
24667141   Curated Info

2

Tucker M (2009) CST Curation Set: 8369; Year: 2009; Biosample/Treatment: tissue, skin/untreated; Disease: melanoma skin cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

3

Zhou J (2009) CST Curation Set: 7722; Year: 2009; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Tucker M (2009) CST Curation Set: 6042; Year: 2009; Biosample/Treatment: tissue, skin/untreated; Disease: melanoma skin cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

5

Whitney G, et al. (2001) A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33. Eur J Biochem 268, 6083-96
11733002   Curated Info

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