Ser468
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Home > Phosphorylation Site Page: > Ser468  -  SMAD1 (rat)

Site Information
HNPISsVs_______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448363

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , mass spectrometry ( 1 , 2 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
heart ( 1 ) , intestine ( 1 ) , kidney ( 1 ) , liver ( 1 , 2 ) , lung ( 1 ) , mesangial-kidney ( 3 ) , stomach ( 1 )

Upstream Regulation
Regulatory protein:
LRP1 (rat) ( 3 )
Putative in vivo kinases:
Src (rat) ( 3 )
Treatments:
angiotensin_2 ( 3 ) , anti-PDGFR ( 3 ) , anti-TGFB1 ( 3 ) , PDGF ( 3 ) , PP2 ( 3 ) , siRNA ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, induced ( 3 ) , signaling pathway regulation ( 3 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729
21738781   Curated Info

3

Mima A, et al. (2011) Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis. PLoS One 6, e17929
21445358   Curated Info