Ser224

Site Information
KIPRGPPsPPAPVMH GenPept Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 455764

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:	'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , adipose tissue ( 2 ) , heart ( 2 ) , IEC-6 (epithelial) ( 1 ) , intestine ( 2 ) , kidney ( 2 ) , liver ( 2 , 3 , 4 ) , lung ( 2 ) , muscle ( 2 ) , spleen ( 2 ) , stomach ( 2 ) , testis ( 2 ) , thymus ( 2 )

Upstream Regulation
Treatments:	PD184352 ( 1 ) , serum ( 1 )

References
1	Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669 23712012 Curated Info
2	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
3	Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729 21738781 Curated Info
4	Moser K, White FM (2006) Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS. J Proteome Res 5, 98-104 16396499 Curated Info