Ser369
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Home > Phosphorylation Site Page: > Ser369  -  Cas-L (human)

Site Information
VDGINRLsFSSTGST   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 9471800

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 , 4 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , colorectal cancer ( 2 , 4 ) , colorectal carcinoma ( 2 , 4 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , HCT116 (intestinal) ( 2 , 4 )

Upstream Regulation
Treatments:
hesperadin ( 4 ) , MG132 ( 4 ) , okadaic_acid ( 4 ) , ZM447439 ( 4 )

Downstream Regulation
Effects of modification on Cas-L:
protein degradation ( 2 , 4 )
Effects of modification on biological processes:
cell motility, inhibited ( 2 )
Inhibit interaction with:
FAK (human) ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Ibrahim R, Lemoine A, Bertoglio J, Raingeaud J (2015) Human enhancer of filamentation 1-induced colorectal cancer cell migration: Role of serine phosphorylation and interaction with the breast cancer anti-estrogen resistance 3 protein. Int J Biochem Cell Biol 64, 45-57
25817040   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Hivert V, Pierre J, Raingeaud J (2009) Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation. Biochem Pharmacol 78, 1017-25
19539609   Curated Info

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