Ser45
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Home > Phosphorylation Site Page: > Ser45  -  CTNNB1 (mouse)

Site Information
GATtTAPsLSGkGNP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447488

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 6 ) , mutation of modification site ( 1 , 6 ) , phospho-antibody ( 1 , 2 , 4 , 5 ) , western blotting ( 1 , 2 , 4 , 5 , 6 )
Disease tissue studied:
neuroblastoma ( 6 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 5 ) , intestine [CK1A (mouse), homozygous knockout] ( 4 ) , Neuro-2a (neuron) ( 6 )

Upstream Regulation
Regulatory protein:
CK1A (mouse) ( 2 )
Putative in vivo kinases:
CK1A (mouse) ( 4 ) , CK1E (human) ( 5 ) , GSK3B (mouse) ( 6 ) , PKCZ (mouse) ( 1 )
Kinases, in vitro:
CK1E (human) ( 5 )
Treatments:
LLnL ( 6 )

Downstream Regulation
Effects of modification on CTNNB1:
protein degradation ( 6 ) , ubiquitination ( 6 )

References 

1

Llado V, et al. (2015) Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ Cell Rep
25660024   Curated Info

2

Bowman BM, et al. (2015) Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer. Sci Signal 8, ra9
25628462   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Elyada E, et al. (2011) CKIα ablation highlights a critical role for p53 in invasiveness control. Nature 470, 409-13
21331045   Curated Info

5

Sakanaka C (2002) Phosphorylation and regulation of beta-catenin by casein kinase I epsilon. J Biochem (Tokyo) 132, 697-703
12417018   Curated Info

6

Aberle H, et al. (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16, 3797-804
9233789   Curated Info