Thr704

Site Information
WKLQRAItILDTEKS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 487542

In vivo Characterization
Methods used to characterize site in vivo:	[32P] ATP in vitro ( 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 3 , 4 ) , COS (fibroblast) ( 5 ) , neuron-dorsal root ganglia ( 2 ) , oocyte ( 4 ) , tsA201 (epithelial) ( 1 )

Downstream Regulation
Effects of modification on TRPV1:	activity, induced ( 1 , 3 , 4 , 5 ) , receptor desensitization, altered ( 4 )
Induce interaction with:	RNUXA (human) ( 4 )

References
1	Jendzjowsky NG, et al. (2020) PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines. J Physiol 33180962 Curated Info
2	Loo L, et al. (2012) The C-Type Natriuretic Peptide Induces Thermal Hyperalgesia through a Noncanonical Gβγ-dependent Modulation of TRPV1 Channel. J Neurosci 32, 11942-55 22933780 Curated Info
3	Novakova-Tousova K, et al. (2007) Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization. Neuroscience 149, 144-54 17869438 Curated Info
4	Jung J, et al. (2004) Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem 279, 7048-54 14630912 Curated Info
5	Bhave G, et al. (2003) Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A 100, 12480-5 14523239 Curated Info