Ser433
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Home > Phosphorylation Site Page: > Ser433  -  NBS1 (mouse)

Site Information
KtPsYQLsPMKFPVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 483547

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 , 5 ) , mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:
epithelial-mammary gland ( 1 ) , HEK293T (epithelial) ( 2 ) , macrophage-peritoneum ( 4 ) , MEF (fibroblast) ( 2 ) , spleen ( 5 )

Upstream Regulation
Regulatory protein:
CIP2A (human) ( 1 )
Putative in vivo kinases:
CDK2 (human) ( 2 )
Putative upstream phosphatases:
PPP1CA (human) ( 2 )

Downstream Regulation
Effects of modification on NBS1:
intracellular localization ( 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , DNA repair, altered ( 2 )
Inhibit interaction with:
TRF2 (mouse) ( 2 )

References 

1

Laine A, et al. (2021) CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis. Cancer Res
34145035   Curated Info

2

Rai R, et al. (2017) NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Mol Cell 65, 801-817.e4
28216226   Curated Info

3

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

4

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info