Tyr222
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Home > Phosphorylation Site Page: > Tyr222  -  CRK (chicken)

Site Information
GGPEPGPyAQPSINT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447951

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
adrenal cancer ( 3 ) , pheochromocytoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 3 )
Kinases, in vitro:
Abl (human) ( 3 ) , Arg (human) ( 2 )
Treatments:
NGF ( 3 )

Downstream Regulation
Effects of modification on CRK:
molecular association, regulation ( 1 , 3 ) , protein conformation ( 1 )
Effects of modification on biological processes:
cell adhesion, altered ( 3 ) , cell differentiation, altered ( 3 )
Inhibit interaction with:
Abl (human) ( 1 ) , Abl iso2 (human) ( 3 ) , PXN (chicken) ( 3 )

References 

1

Sarkar P, et al. (2007) Proline cis-trans isomerization controls autoinhibition of a signaling protein. Mol Cell 25, 413-26
17289588   Curated Info

2

Hu H, Bliss JM, Wang Y, Colicelli J (2005) RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol 15, 815-23
15886098   Curated Info

3

Escalante M, et al. (2000) Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. J Biol Chem 275, 24787-97
10825157   Curated Info