Ser473
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Home > Phosphorylation Site Page: > Ser473  -  P70S6KB (human)

Site Information
PPSGTKKsKRGRGRP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450071

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 1 ) , myocyte-heart ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 ) , PKCB (human) ( 1 ) , PKCD (human) ( 1 ) , PKCE (human) ( 1 ) , PKCG (human) ( 1 ) , PKCI (human) ( 1 ) , PKCZ (human) ( 1 )
Kinases, in vitro:
PKCA (human) ( 1 ) , PKCB (human) ( 1 ) , PKCB iso2 (human) ( 1 ) , PKCD (human) ( 1 ) , PKCE (human) ( 1 ) , PKCG (human) ( 1 ) , PKCZ (mouse) ( 1 )

Downstream Regulation
Effects of modification on P70S6KB:
intracellular localization ( 1 )

References 

1

Valovka T, et al. (2003) Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. Mol Cell Biol 23, 852-63
12529391   Curated Info

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