Ser92
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Home > Phosphorylation Site Page: > Ser92  -  PDE5A (mouse)

Site Information
GAPARKIsASEFDRP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448178

In vivo Characterization
Methods used to characterize site in vivo:
microscopy-colocalization with upstream kinase ( 2 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:
'neuron, Purkinje'-'brain, cerebellum' ( 2 ) , VSMC-aorta ( 3 ) , VSMC-aorta [PKG1 (mouse)] ( 3 )

Upstream Regulation
Putative in vivo kinases:
PKG1 (mouse) ( 2 , 3 )
Treatments:
calyculin_A ( 3 ) , cAMP_analog ( 2 , 3 ) , cGMP_analog ( 2 , 3 ) , colforsin ( 2 ) , H-89 ( 2 ) , IBMX ( 2 ) , ODQ ( 2 ) , okadaic_acid ( 3 ) , sildenafil ( 2 ) , SNP ( 2 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Shimizu-Albergine M, et al. (2003) Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation. J Neurosci 23, 6452-9
12878685   Curated Info

3

Rybalkin SD, et al. (2002) Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells. J Biol Chem 277, 3310-7
11723116   Curated Info