Ser502
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Home > Phosphorylation Site Page: > Ser502  -  TRPV1 (human)

Site Information
YFLQRRPsMKTLFVD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450016

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 4 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 , 4 ) , CHO-K1 (fibroblast) ( 1 ) , HeLa (cervical) ( 1 ) , MEF (fibroblast) ( 1 ) , neuron-dorsal root ganglia ( 2 , 3 )

Upstream Regulation
Regulatory protein:
AKAP5 (human) ( 4 ) , Spinophilin (human) ( 2 ) , Spinophilin (mouse) ( 2 )
Putative in vivo kinases:
PKACA (human) ( 4 ) , PKCA (human) ( 4 )
Treatments:
bradykinin ( 4 ) , colforsin ( 4 ) , formaldehyde ( 2 ) , H-89 ( 4 ) , PGE2 ( 4 )

Downstream Regulation
Effects of modification on TRPV1:
intracellular localization ( 2 , 4 ) , receptor desensitization, altered ( 4 )

References 

1

Zhao X, et al. (2020) PKCε SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain. Cell Rep 33, 108191
33027667   Curated Info

2

Guo Z, et al. (2019) Spinophilin negatively controlled the function of transient receptor potential vanilloid 1 in dorsal root ganglia neurons of mice. Eur J Pharmacol 863, 172700
31563651   Curated Info

3

Li L, Hasan R, Zhang X (2014) The Basal Thermal Sensitivity of the TRPV1 Ion Channel Is Determined by PKCβII. J Neurosci 34, 8246-58
24920628   Curated Info

4

Zhang X, Li L, McNaughton PA (2008) Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron 59, 450-61
18701070   Curated Info

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