Thr149
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr149  -  Tau iso8 (human)

Site Information
AKGADGKtKIAtPRG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 487446

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 )
Disease tissue studied:
Alzheimer's disease ( 2 )
Relevant cell line - cell type - tissue:
brain ( 2 )

Upstream Regulation
Putative in vivo kinases:
LRRK2 (human) ( 1 )

Downstream Regulation
Effects of modification on Tau iso8:
molecular association, regulation ( 1 )
Induce interaction with:
Tau iso8 (human) ( 1 )

References 

1

Bailey RM, et al. (2013) LRRK2 phosphorylates novel tau epitopes and promotes tauopathy. Acta Neuropathol 126, 809-27
24113872   Curated Info

2

Hanger DP, et al. (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-54
17562708   Curated Info