Tyr900
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Home > Phosphorylation Site Page: > Tyr900  -  Kit (human)

Site Information
EHAPAEMyDIMKTCW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450042

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , phosphoamino acid analysis ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 1 ) , PAE (endothelial) ( 1 )

Upstream Regulation
Kinases, in vitro:
Src iso1 (mouse) ( 1 )
Treatments:
SU6656 ( 1 )

Downstream Regulation
Effects of modification on Kit:
molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Induce interaction with:
CRK (human) ( 1 ) , PIK3C2A (human) ( 1 )

References 

1

Lennartsson J, et al. (2003) Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. Exp Cell Res 288, 110-8
12878163   Curated Info