Thr35
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Home > Phosphorylation Site Page: > Thr35  -  PPP1R1A (rabbit)

Site Information
QIRRRRPtPATLVLT   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447759

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 3 ) , [32P] bio-synthetic labeling ( 4 ) , peptide sequencing ( 3 ) , phospho-antibody ( 2 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 4 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'heart, ventricle' ( 2 ) , 'muscle, skeletal' ( 3 , 4 ) , E.coli (bacterial) ( 1 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 1 , 4 )

Downstream Regulation
Effects of modification on PPP1R1A:
enzymatic activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
PPP1CA (human) ( 1 )

References 

1

Liang CT, et al. (2018) Characterization of the interactions between inhibitor-1 and recombinant PP1 by NMR spectroscopy. Sci Rep 8, 50
29311589   Curated Info

2

Tsuji Y, et al. (2011) Ca2+-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation 123, 2192-203
21555709   Curated Info

3

Aitken A, Bilham T, Cohen P (1982) Complete primary structure of protein phosphatase inhibitor-1 from rabbit skeletal muscle. Eur J Biochem 126, 235-46
6290217   Curated Info

4

Nimmo GA, Cohen P (1978) The regulation of glycogen metabolism. Purification and characterisation of protein phosphatase inhibitor-1 from rabbit skeletal muscle. Eur J Biochem 87, 341-51
208844   Curated Info