Tyr466
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Home > Phosphorylation Site Page: > Tyr466  -  IFNAR1 (human)

Site Information
VFLRCINyVFFPSLK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450029

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 5 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 5 ) , HeLa (cervical) ( 1 )

Upstream Regulation
Kinases, in vitro:
Tyk2 (human) ( 5 )
Putative upstream phosphatases:
PTP1B (human) ( 2 )
Phosphatases, in vitro:
PTP1B (human) ( 2 )

Downstream Regulation
Effects of modification on IFNAR1:
molecular association, regulation ( 3 , 4 , 5 ) , phosphorylation ( 5 ) , protein stabilization ( 2 ) , receptor internalization, inhibited ( 2 )
Effects of modification on biological processes:
transcription, induced ( 2 )
Induce interaction with:
STAT1 (human) ( 4 ) , STAT2 (human) ( 3 , 4 , 5 )

References 

1

Shemesh M, Lochte S, Piehler J, Schreiber G (2021) IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. Sci Signal 14, eabe4627
34813358   Curated Info

2

Carbone CJ, et al. (2012) Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proc Natl Acad Sci U S A 109, 19226-31
23129613   Curated Info

3

Saleh AZ, Nguyen VP, Krolewski JJ (2002) Affinity of Stat2 for the subunits of the interferon alpha receptor. Biochemistry 41, 11261-8
12220192   Curated Info

4

Li X, Leung S, Kerr IM, Stark GR (1997) Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol Cell Biol 17, 2048-56
9121453   Curated Info

5

Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J 15, 1064-74
8605876   Curated Info

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