Ser800
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Home > Phosphorylation Site Page: > Ser800  -  TRPV1 (rat)

Site Information
VPLLRDAsTRDRHAT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450017

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 4 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ) , phospho-antibody ( 2 , 3 , 5 , 7 ) , western blotting ( 5 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 7 , 8 , 9 ) , CHO (fibroblast) ( 11 ) , COS (fibroblast) ( 13 ) , F11 (neuron) ( 6 ) , HEK293T (epithelial) ( 10 ) , HeLa (cervical) ( 10 ) , neuron ( 3 , 5 , 6 ) , neuron-dorsal root ganglia ( 2 , 4 , 9 ) , oocyte ( 12 , 14 )

Upstream Regulation
Regulatory protein:
AKAP5 (rat) ( 3 , 5 )
Putative in vivo kinases:
PKCA (human) ( 1 , 3 , 5 , 7 , 8 ) , PKCE (rat) ( 6 )
Kinases, in vitro:
PKCA (human) ( 13 ) , PKCE (rat) ( 6 , 15 )
Treatments:
bisindolylmaleimide ( 1 , 6 , 7 ) , calphostin_C ( 7 ) , capsaicin ( 7 , 8 ) , DHPG ( 3 ) , endothelin ( 7 ) , estradiol ( 6 ) , GF109203X ( 3 , 5 ) , Go_6976 ( 1 ) , mono-iodoacetate (MIA)-induced joint pain model ( 2 ) , NMDA ( 5 ) , phorbol_ester ( 3 , 5 , 7 , 8 , 15 )

Downstream Regulation
Effects of modification on TRPV1:
activity, induced ( 3 , 4 , 7 , 8 , 9 , 13 , 14 ) , molecular association, regulation ( 6 ) , receptor desensitization, altered ( 11 , 12 , 13 ) , receptor desensitization, inhibited ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 6 )
Inhibit interaction with:
TUBA1A (human) ( 6 )

Disease / Diagnostics Relevance
Relevant diseases:
muscle mechanical hyperalgesia ( 3 )

References 

1

Liu L, Yudin Y, Rohacs T (2020) Diacylglycerol kinases regulate TRPV1 channel activity. J Biol Chem
32345612   Curated Info

2

Koda K, et al. (2016) Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain. Osteoarthritis Cartilage 24, 1254-62
26970286   Curated Info

3

Chung MK, et al. (2015) Peripheral Group I Metabotropic Glutamate Receptor Activation Leads to Muscle Mechanical Hyperalgesia Through TRPV1 Phosphorylation in the Rat. J Pain 16, 67-76
25451626   Curated Info

4

Loo L, et al. (2012) The C-Type Natriuretic Peptide Induces Thermal Hyperalgesia through a Noncanonical Gβγ-dependent Modulation of TRPV1 Channel. J Neurosci 32, 11942-55
22933780   Curated Info

5

Lee J, Chung MK, Ro JY (2012) Activation of NMDA receptors leads to phosphorylation of TRPV1 S800 by protein kinase C and A-Kinase anchoring protein 150 in rat trigeminal ganglia. Biochem Biophys Res Commun 424, 358-63
22789851   Curated Info

6

Goswami C, et al. (2011) Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway. J Neurochem 117, 995-1008
21480900   Curated Info

7

Kawamata T, et al. (2008) Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia. Neuroscience 154, 1067-76
18495351   Curated Info

8

Chung MK, Güler AD, Caterina MJ (2008) TRPV1 shows dynamic ionic selectivity during agonist stimulation. Nat Neurosci 11, 555-64
18391945   Curated Info

9

Plant TD, et al. (2007) Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C. Mol Pain 3, 35
18001466   Curated Info

10

Mohapatra DP, Nau C (2005) Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 280, 13424-32
15691846   Curated Info

11

Mandadi S, et al. (2004) Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels. Cell Calcium 35, 471-8
15003856   Curated Info

12

Premkumar LS, Qi ZH, Van Buren J, Raisinghani M (2004) Enhancement of potency and efficacy of NADA by PKC-mediated phosphorylation of vanilloid receptor. J Neurophysiol 91, 1442-9
14973326   Curated Info

13

Bhave G, et al. (2003) Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A 100, 12480-5
14523239   Curated Info

14

Ahern GP (2003) Activation of TRPV1 by the satiety factor oleoylethanolamide. J Biol Chem 278, 30429-34
12761211   Curated Info

15

Numazaki M, Tominaga T, Toyooka H, Tominaga M (2002) Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem 277, 13375-8
11884385   Curated Info

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