Ser262
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Home > Phosphorylation Site Page: > Ser262  -  GATA4 (human)

Site Information
IkPQRRLsAsRRVGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450013

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 3 )
Relevant cell line - cell type - tissue:
CV1 (fibroblast) ( 1 ) , MCF-7 (breast cell) ( 3 ) , MKN-45 (gastric) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 3 ) , PKG1 (human) ( 1 )
Kinases, in vitro:
PKG1 (human) ( 1 )

Downstream Regulation
Effects of modification on GATA4:
activity, induced ( 3 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 , 3 )
Induce interaction with:
DNA ( 1 )

References 

1

Ma Y, Wang J, Yu Y, Schwartz RJ (2016) PKG-1α mediates GATA4 transcriptional activity. Cell Signal 28, 585-94
26946174   Curated Info

2

Moritz A (2007) CST Curation Set: 3608; Year: 2007; Biosample/Treatment: cell line, MKN-45/Su11274; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

3

Bouchard MF, Taniguchi H, Viger RS (2005) Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells. Endocrinology 146, 4905-16
16109788   Curated Info

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