Ser261
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Home > Phosphorylation Site Page: > Ser261  -  GATA4 (rat)

Site Information
IKPQRRLsASRRVGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450013

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
H9c2 (myoblast) ( 1 , 2 ) , MA-10 (testicular) ( 4 ) , myocyte-heart ( 2 )

Upstream Regulation
Regulatory protein:
ERK1 (human) ( 2 ) , NHE1 (rat) ( 1 ) , p90RSK (rat) ( 1 )
Putative in vivo kinases:
PKACA (mouse) ( 4 ) , RSK2 (human) ( 2 )
Kinases, in vitro:
PKACA (rat) ( 4 )
Treatments:
BI-D1870 ( 1 ) , EMD_87580 ( 1 ) , H-89 ( 4 ) , PD90059 ( 4 ) , phenylephrine ( 1 , 2 ) , SB203580 ( 4 ) , SL0101 ( 2 )

Downstream Regulation
Effects of modification on GATA4:
activity, induced ( 4 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell growth, induced ( 2 ) , transcription, induced ( 2 , 4 )
Induce interaction with:
DNA ( 2 ) , NKX2-5 (human) ( 2 ) , p300 (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
hypertrophic cardiomyopathy ( 2 )

References 

1

Jaballah M, et al. (2015) Na+/H+ Exchanger Isoform 1 Induced Cardiomyocyte Hypertrophy Involves Activation of p90 Ribosomal S6 Kinase. PLoS One 10, e0122230
25830299   Curated Info

2

Li T, et al. (2012) Involvement of ERK-RSK cascade in phenylephrine-induced phosphorylation of GATA4. Biochim Biophys Acta 1823, 582-92
22227582   Curated Info

3

Kwintkiewicz J, Cai Z, Stocco C (2007) Follicle-stimulating hormone-induced activation of Gata4 contributes in the up-regulation of Cyp19 expression in rat granulosa cells. Mol Endocrinol 21, 933-47
17227882   Curated Info

4

Tremblay JJ, Viger RS (2003) Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells. J Biol Chem 278, 22128-35
12670947   Curated Info