Ser406
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Home > Phosphorylation Site Page: > Ser406  -  GABRB3 (mouse)

Site Information
GIQYRKQsMPKEGHG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486453

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 , 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 2 ) , neuron-'brain, hippocampus' ( 1 ) , NG108-15 (neuron) ( 3 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (rat) ( 3 )
Treatments:
4-AP ( 1 ) , BayK8644 ( 1 ) , KN-93 ( 1 ) , nimodipine ( 1 ) , TTX ( 1 )

Downstream Regulation
Effects of modification on GABRB3:
activity, induced ( 1 , 3 )

References 

1

Saliba RS, Kretschmannova K, Moss SJ (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. EMBO J 31, 2937-51
22531784   Curated Info

2

Kang SU, Heo S, Lubec G (2011) Mass spectrometric analysis of GABA(A) receptor subtypes and phosphorylations from mouse hippocampus. Proteomics 11, 2171-81
21538884   Curated Info

3

Houston CM, et al. (2007) Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors. J Biol Chem 282, 17855-65
17442679   Curated Info