Ser365
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Home > Phosphorylation Site Page: > Ser365  -  GABRG2 (mouse)

Site Information
FVSNRkPskDkDkkk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486436

In vivo Characterization
Methods used to characterize site in vivo:
western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' [PKCE (mouse), homozygous knockout] ( 1 ) , 'brain, hippocampus' [PKCE (mouse), homozygous knockout] ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCE (mouse) ( 1 )
Kinases, in vitro:
PKCA (rat) ( 2 )
Treatments:
ethanol ( 1 )

Downstream Regulation
Effects of modification on GABRG2:
receptor desensitization, altered ( 1 )

References 

1

Qi ZH, et al. (2007) Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem 282, 33052-63
17875639   Curated Info

2

Moss SJ, Doherty CA, Huganir RL (1992) Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor. J Biol Chem 267, 14470-6
1321150   Curated Info