Tyr405
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Home > Phosphorylation Site Page: > Tyr405  -  GABRG2 iso2 (mouse)

Site Information
ERDEEyGyECLDGKD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455818

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus, dentate gyrus' ( 1 ) , 'brain, thalamus' [GABRG2 (mouse), genetic knockin] ( 2 ) , 'neuron, cerebellar granule'-brain ( 3 ) , neuron-'brain, cerebral cortex' ( 1 ) , NG108-15 (neuron) ( 3 )

Upstream Regulation
Regulatory protein:
CAMK2A (rat) ( 3 )
Treatments:
BDNF ( 1 ) , depolarization ( 3 )

Downstream Regulation
Effects of modification on GABRG2 iso2:
activity, induced ( 1 , 3 ) , receptor inactivation, induced ( 2 ) , receptor internalization, inhibited ( 1 )
Effects of modification on biological processes:
neural plasticity ( 1 )

References 

1

Vithlani M, et al. (2013) The Ability of BDNF to Modify Neurogenesis and Depressive-Like Behaviors Is Dependent upon Phosphorylation of Tyrosine Residues 365/367 in the GABAA-Receptor γ2 Subunit. J Neurosci 33, 15567-77
24068823   Curated Info

2

Nani F, et al. (2013) Tyrosine Phosphorylation of GABAA Receptor γ2-Subunit Regulates Tonic and Phasic Inhibition in the Thalamus. J Neurosci 33, 12718-27
23904608   Curated Info

3

Houston CM, et al. (2007) Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors. J Biol Chem 282, 17855-65
17442679   Curated Info