Ser1457
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Home > Phosphorylation Site Page: > Ser1457  -  BRCA1 (human)

Site Information
SEKAVLTsQKsSEYP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450008

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 10 ) , electrophoretic mobility shift ( 9 , 10 ) , mass spectrometry ( 6 , 7 , 10 ) , mutation of modification site ( 2 , 5 , 10 ) , phospho-antibody ( 1 , 5 , 8 , 9 ) , western blotting ( 1 , 2 , 5 , 9 )
Disease tissue studied:
ataxia-telangiectasia ( 9 ) , brain cancer ( 5 ) , glioblastoma ( 5 ) , glioma ( 5 ) , breast cancer ( 2 , 5 ) , breast ductal carcinoma ( 2 ) , breast cancer, triple negative ( 2 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
BRCA1 (human) ( 1 ) , GADD45A (human) ( 1 )
Putative in vivo kinases:
ATM (human) ( 9 ) , ATR (human) ( 8 )
Kinases, in vitro:
ATM (human) ( 9 , 10 )
Treatments:
DIM ( 5 ) , ionizing_radiation ( 8 , 9 , 10 ) , lncRNAs ( 1 ) , UV ( 8 )

Downstream Regulation
Effects of modification on BRCA1:
molecular association, regulation ( 10 )
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , DNA repair, altered ( 2 )
Induce interaction with:
ATM (human) ( 10 )

Disease / Diagnostics Relevance
Relevant diseases:
ataxia-telangiectasia ( 9 )

References 

1

Mazar J, et al. (2017) The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis through activation of BRCA1 and p53 in human neuroblastoma. Oncotarget 8, 6589-6607
28035057   Curated Info

2

Beckta JM, et al. (2015) Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget 6, 27674-87
26320175   Curated Info

3

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

4

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

5

Fan S, et al. (2009) Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res 69, 6083-91
19622773   Curated Info

6

Zhou J (2009) CST Curation Set: 6048; Year: 2009; Biosample/Treatment: cell line, Jurkat/untreated; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M)
Curated Info

7

Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6
17525332   Curated Info

8

Gatei M, et al. (2001) Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J Biol Chem 276, 17276-80
11278964   Curated Info

9

Gatei M, et al. (2000) Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res 60, 3299-304
10866324   Curated Info

10

Cortez D, Wang Y, Qin J, Elledge SJ (1999) Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286, 1162-6
10550055   Curated Info