Ser458
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Home > Phosphorylation Site Page: > Ser458  -  CAMKK1 (rat)

Site Information
KSMLRKRsFGNPFEP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486077

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 1 ) , 'brain, cerebellum' ( 1 ) , 'brain, cerebral cortex' ( 1 ) , COS (fibroblast) ( 3 ) , intestine ( 1 ) , Jurkat (T lymphocyte) ( 3 ) , kidney ( 1 ) , lung ( 1 ) , spleen ( 1 ) , thymus ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (rat) ( 3 )
Kinases, in vitro:
PKACA (human) ( 2 )

Downstream Regulation
Effects of modification on CAMKK1:
enzymatic activity, inhibited ( 3 ) , molecular association, regulation ( 3 )
Inhibit interaction with:
Calmodulin (human) ( 3 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Okuno S, Kitani T, Fujisawa H (2001) Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis. J Biochem 130, 503-13
11574070   Curated Info

3

Wayman GA, Tokumitsu H, Soderling TR (1997) Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent protein kinase cascade. J Biol Chem 272, 16073-6
9195898   Curated Info