Thr256
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Home > Phosphorylation Site Page: > Thr256  -  SGK1 (rat)

Site Information
EHNGTTstFCGTPEY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448431

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , 32D (myeloid) ( 2 ) , 3T3 (fibroblast) ( 2 ) , 3T3-L1 (fibroblast) ( 2 ) , granulosa ( 1 ) , hepatocyte ( 2 )

Upstream Regulation
Putative in vivo kinases:
PDK1 (human) ( 3 )
Kinases, in vitro:
PDK1 (rat) ( 3 )
Treatments:
LY294002 ( 3 ) , TGF-beta ( 1 ) , urofollitropin ( 1 ) , vanadate ( 3 )

Downstream Regulation
Effects of modification on SGK1:
enzymatic activity, induced ( 3 )

References 

1

Chen YJ, et al. (2007) Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFbeta1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells. J Endocrinol 192, 405-19
17283241   Curated Info

2

Sakoda H, et al. (2003) Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem 278, 25802-7
12734207   Curated Info

3

Park J, et al. (1999) Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18, 3024-33
10357815   Curated Info