Ser421
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Home > Phosphorylation Site Page: > Ser421  -  SGK1 (rat)

Site Information
AEAFLGFsYAPPMDS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448429

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 5 ) , phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 2 , 4 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , 293 (epithelial) ( 5 ) , 32D (myeloid) ( 4 ) , 3T3 (fibroblast) ( 4 ) , 3T3-L1 (fibroblast) ( 4 ) , HEK293T (epithelial) ( 1 , 2 ) , HeLa (cervical) ( 2 ) , hepatocyte ( 4 ) , neuron-'brain, hippocampus' ( 2 ) , PC-12 (chromaffin) ( 1 , 3 )

Upstream Regulation
Treatments:
BDNF ( 3 ) , dexamethasone ( 2 ) , IGF-1 ( 3 ) , learning ( 1 ) , LY294002 ( 5 ) , neurotrophin-3 ( 3 ) , neurotrophin-4 ( 3 ) , NGF ( 3 ) , vanadate ( 5 )

Downstream Regulation
Effects of modification on SGK1:
enzymatic activity, induced ( 1 , 5 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Tyan SW, et al. (2008) Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation. J Neurochem 105, 820-32
18088355   Curated Info

2

Yang YC, Lin CH, Lee EH (2006) Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Mol Cell Biol 26, 8357-70
16982696   Curated Info

3

Gan L, et al. (2005) Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. J Neurochem 93, 1209-19
15934941   Curated Info

4

Sakoda H, et al. (2003) Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem 278, 25802-7
12734207   Curated Info

5

Park J, et al. (1999) Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18, 3024-33
10357815   Curated Info