Ser685
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser685  -  GRK2 (cow)

Site Information
VPLIQRGsANGL___   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447726

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , neuron-dorsal root ganglia ( 1 )

Upstream Regulation
Regulatory protein:
AKAP1 (human) ( 1 )
Kinases, in vitro:
PKACA (human) ( 2 )
Treatments:
cAMP_analog ( 1 )

Downstream Regulation
Effects of modification on GRK2:
intracellular localization ( 1 ) , molecular association, regulation ( 1 , 2 )
Induce interaction with:
ADRB2 (human) ( 2 ) , DOR-1 (rat) ( 1 )

References 

1

Brackley AD, et al. (2017) Identification of a signaling cascade that maintains constitutive δ-opioid receptor incompetence in peripheral sensory neurons. J Biol Chem 292, 8762-8772
28381559   Curated Info

2

Cong M, et al. (2001) Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem 276, 15192-9
11278469   Curated Info