Thr38
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Home > Phosphorylation Site Page: > Thr38  -  PPP1R14A (pig)

Site Information
QKRHARVtVKYDRRE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449098

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'muscle, smooth'-'heart, artery' ( 2 , 3 ) , REF52 (fibroblast) ( 3 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 1 )
Treatments:
development ( 2 ) , hypoxia ( 2 )

Downstream Regulation
Effects of modification on PPP1R14A:
activity, induced ( 3 ) , protein conformation ( 1 )

References 

1

Eto M, et al. (2007) Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Structure 15, 1591-602
18073109   Curated Info

2

Dakshinamurti S, Mellow L, Stephens NL (2005) Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: a role for CPI-17. Pediatr Pulmonol 40, 398-407
16130142   Curated Info

3

Hayashi Y, et al. (2001) Defining the structural determinants and a potential mechanism for inhibition of myosin phosphatase by the protein kinase C-potentiated inhibitor protein of 17 kDa. J Biol Chem 276, 39858-63
11517233   Curated Info