Ser330
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Home > Phosphorylation Site Page: > Ser330  -  GJA1 (mouse)

Site Information
AGstIsNsHAQPFDF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449994

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 , 5 , 6 , 8 , 9 ) , mutation of modification site ( 1 , 2 , 3 , 7 ) , phospho-antibody ( 2 , 10 ) , western blotting ( 2 , 7 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 4 ) , 'brain, cerebral cortex' ( 9 ) , 'fat, brown' ( 8 ) , brain ( 3 , 8 ) , heart ( 2 , 7 , 8 , 10 ) , KO ( 10 ) , lung ( 8 ) , MDCK (epithelial) ( 2 ) , MEF (fibroblast) ( 5 , 6 ) , muscle ( 1 ) , myocyte-heart ( 1 ) , testis ( 8 )

Upstream Regulation
Treatments:
ischemia ( 7 , 10 )

Downstream Regulation
Effects of modification on GJA1:
intracellular localization ( 7 , 10 ) , molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 ) , endocytosis, inhibited ( 7 ) , signaling pathway regulation ( 2 )
Induce interaction with:
TUBB (human) ( 1 )
Inhibit interaction with:
ERK1 (mouse) ( 2 )

References 

1

Himelman E, et al. (2022) A microtubule-connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice. Am J Physiol Heart Circ Physiol 323, H983-H995
36206047   Curated Info

2

Solan JL, Marquez-Rosado L, Lampe PD (2019) Cx43 phosphorylation mediated effects on ERK and Akt protect against ischemia reperfusion injury and alter stability of stress-inducible protein NDRG1. J Biol Chem
31189653   Curated Info

3

Freitas-Andrade M, et al. (2019) Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke. J Exp Med 216, 916-935
30872361   Curated Info

4

Schindler J, Ye J, Jensen ON, Nothwang HG (2013) Monitoring the native phosphorylation state of plasma membrane proteins from a single mouse cerebellum. J Neurosci Methods 213, 153-64
23246975   Curated Info

5

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

6

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

7

Remo BF, et al. (2011) Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias. Circ Res 108, 1459-66
21527737   Curated Info

8

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

9

Munton RP, et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics 6, 283-93
17114649   Curated Info

10

Lampe PD, Cooper CD, King TJ, Burt JM (2006) Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart. J Cell Sci 119, 3435-42
16882687   Curated Info

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