Ser330
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Home > Phosphorylation Site Page: > Ser330  -  GJA1 (rat)

Site Information
AGstIsNsHAQPFDF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449994

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 6 ) , mass spectrometry ( 2 , 3 , 5 , 6 ) , mass spectrometry (in vitro) ( 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 3 ) , 'brain, cerebellum' ( 3 ) , 'brain, cerebral cortex' ( 3 ) , heart ( 3 , 5 ) , IEC-6 (epithelial) ( 2 ) , intestine ( 3 ) , NRK (fibroblast) ( 6 ) , spleen ( 3 ) , testis ( 3 )

Upstream Regulation
Putative in vivo kinases:
CK1A (human) ( 6 )
Kinases, in vitro:
CAMK2A (human) ( 4 ) , CK1A (human) ( 6 )
Treatments:
ischemia ( 5 ) , PD184352 ( 2 ) , serum ( 2 )

Downstream Regulation
Effects of modification on GJA1:
intracellular localization ( 6 )
Effects of modification on biological processes:
cell adhesion, altered ( 6 )

References 

1

Sakurai T, Tsuchida M, Lampe PD, Murakami M (2013) Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenance. Exp Cell Res 319, 2152-65
23742896   Curated Info

2

Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669
23712012   Curated Info

3

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

4

Huang RY, et al. (2011) Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. J Proteome Res 10, 1098-109
21158428   Curated Info

5

Axelsen LN, et al. (2006) Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J Mol Cell Cardiol 40, 790-8
16678851   Curated Info

6

Cooper CD, Lampe PD (2002) Casein kinase 1 regulates connexin-43 gap junction assembly. J Biol Chem 277, 44962-8
12270943   Curated Info