Ser328
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Home > Phosphorylation Site Page: > Ser328  -  GJA1 (human)

Site Information
GQAGstIsNsHAQPF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449993

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Disease tissue studied:
breast cancer ( 2 )
Relevant cell line - cell type - tissue:
CHO (fibroblast) ( 4 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 2 ) , HMLER ('stem, breast cancer') ( 2 ) , MDCK (epithelial) ( 4 ) , myocyte-heart ( 1 )

Upstream Regulation
Kinases, in vitro:
CK1A (human) ( 3 )

Downstream Regulation
Effects of modification on GJA1:
intracellular localization ( 1 ) , phosphorylation ( 1 ) , protein conformation ( 3 )
Effects of modification on biological processes:
transcription, altered ( 1 )

References 

1

Al-Attar R, et al. (2024) Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes. Biomolecules 14
38254663   Curated Info

2

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

3

Grosely R, et al. (2013) Effects of Phosphorylation on the Structure and Backbone Dynamics of the Intrinsically Disordered Connexin43 C-terminal Domain. J Biol Chem 288, 24857-70
23828237   Curated Info

4

Solan JL, Lampe PD (2007) Key connexin 43 phosphorylation events regulate the gap junction life cycle. J Membr Biol 217, 35-41
17629739   Curated Info

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