Ser362
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Home > Phosphorylation Site Page: > Ser362  -  CK2A1 (human)

Site Information
ISSVPtPsPLGPLAG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449986

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioblastoma multiforme ( 2 ) , glioma ( 2 ) , liver cancer ( 1 ) , hepatocellular carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ERK1 (human) ( 2 )
Putative in vivo kinases:
ERK2 (human) ( 1 , 3 )
Kinases, in vitro:
CDK1 (human) ( 5 ) , ERK2 (human) ( 1 , 3 )

Downstream Regulation
Effects of modification on CK2A1:
enzymatic activity, induced ( 3 ) , molecular association, regulation ( 1 , 2 )
Induce interaction with:
CK2A1 (human) ( 1 ) , PGK1 (human) ( 2 )

References 

1

Liu T, et al. (2023) Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth. Nat Cell Biol 25, 273-284
36646788   Curated Info

2

Li X, et al. (2018) Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Mol Cell 72, 650-660.e8
30392930   Curated Info

3

Ji H, et al. (2009) EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell 36, 547-59
19941816   Curated Info

4

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info

5

Bosc DG, Slominski E, Sichler C, Litchfield DW (1995) Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro. J Biol Chem 270, 25872-8
7592773   Curated Info