Lys377
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Home > Ubiquitylation Site Page: > Lys377  -  RIPK1 (human)

Site Information
NEPSLQSkLQDEANy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486338

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 7 ) , immunoprecipitation ( 3 , 4 , 5 , 6 ) , mutation of modification site ( 3 , 4 , 5 , 6 , 7 , 8 ) , western blotting ( 3 , 4 , 5 , 6 , 7 , 8 )
Disease tissue studied:
leukemia ( 4 , 5 , 7 , 8 ) , T cell leukemia ( 4 , 5 , 7 , 8 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 ) , lymphoma ( 4 ) , Burkitt's lymphoma ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 8 ) , 3T3 (fibroblast) ( 4 ) , A549 (pulmonary) ( 3 ) , BJAB (B lymphocyte) ( 4 ) , HEK293T (epithelial) ( 4 , 7 ) , Jurkat (T lymphocyte) ( 4 , 5 , 7 , 8 ) , MEF (fibroblast) ( 6 )

Upstream Regulation
Regulatory protein:
cIAP2 (human) ( 4 ) , FAIM3 (human) ( 5 ) , MALT1 (human) ( 4 ) , TNF-a (human) ( 8 )
Treatments:
Fas ( 5 ) , TNF ( 7 ) , virus infection ( 6 )

Downstream Regulation
Effects of modification on RIPK1:
enzymatic activity, induced ( 8 ) , enzymatic activity, inhibited ( 6 ) , molecular association, regulation ( 5 , 7 , 8 ) , phosphorylation ( 6 ) , protein degradation ( 6 ) , protein processing ( 6 )
Effects of modification on biological processes:
apoptosis, inhibited ( 5 , 7 , 8 ) , carcinogenesis, induced ( 4 ) , cell growth, induced ( 4 ) , signaling pathway regulation ( 4 ) , transcription, induced ( 4 , 8 ) , transcription, inhibited ( 3 )
Induce interaction with:
FADD (human) ( 5 ) , IKKB (human) ( 8 ) , IKKG (human) ( 8 ) , TAB2 (human) ( 8 ) , TAK1 (human) ( 7 , 8 )

References 

1

Feltham R, et al. (2018) Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. Cell Rep
29642005   Curated Info

2

Zeng F, et al. (2018) RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis. Cancer Res
29531160   Curated Info

3

He M, et al. (2016) The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1. Sci Rep 6, 27597
27270888   Curated Info

4

Rosebeck S, et al. (2014) The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-κB signaling. Oncogene 33, 2520-30
23770847   Curated Info

5

Nguyen XH, et al. (2011) Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood 118, 598-608
21613257   Curated Info

6

Rajput A, et al. (2011) RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein. Immunity 34, 340-51
21419663   Curated Info

7

Li H, et al. (2006) Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem 281, 13636-43
16543241   Curated Info

8

Ea CK, et al. (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22, 245-57
16603398   Curated Info

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