Lys49
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Home > Ubiquitylation Site Page: > Lys49  -  CTNNB1 (human)

Site Information
TAPsLsGkGNPEEED   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486322

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , RK3E (epithelial) ( 1 )

Downstream Regulation
Effects of modification on CTNNB1:
protein degradation ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , cell growth, inhibited ( 1 ) , transcription, inhibited ( 1 )

References 

1

Winer IS, Bommer GT, Gonik N, Fearon ER (2006) Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation. J Biol Chem 281, 26181-7
16849322   Curated Info