Ser993
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Home > Phosphorylation Site Page: > Ser993  -  CD45 (mouse)

Site Information
SEPEsDEssDDDsDS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449973

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (mouse) ( 2 )
Kinases, in vitro:
CK2A1 (mouse) ( 2 )
Phosphatases, in vitro:
PPP2CA (mouse) ( 2 )

Downstream Regulation
Effects of modification on CD45:
enzymatic activity, induced ( 2 )

References 

1

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

2

Wang Y, Guo W, Liang L, Esselman WJ (1999) Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis. J Biol Chem 274, 7454-61
10066810   Curated Info