Ser365
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Home > Phosphorylation Site Page: > Ser365  -  JIP3 (human)

Site Information
RLDRtGssPTQGIVN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486175

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 9 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ) , mass spectrometry (in vitro) ( 9 ) , western blotting ( 9 )
Disease tissue studied:
breast cancer ( 3 ) , breast ductal carcinoma ( 3 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 , 3 ) , lung cancer ( 4 ) , non-small cell lung adenocarcinoma ( 4 ) , neuroblastoma ( 6 ) , ovarian cancer ( 3 ) , cancer, squamous cell carcinoma ( 9 ) , FTLD ( 7 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 7 ) , breast ( 1 , 3 ) , HeLa (cervical) ( 2 ) , Jurkat (T lymphocyte) ( 5 , 8 ) , lung ( 4 ) , NB10 (neural crest) ( 6 ) , NPC (neural crest) ( 6 ) , ovary ( 3 ) , SCC28 (squamous) ( 9 )

Upstream Regulation
Putative in vivo kinases:
ROCK1 (human) ( 9 )
Kinases, in vitro:
ROCK1 (human) ( 9 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

5

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

6

DeNardo BD, et al. (2013) Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. PLoS One 8, e82513
24349301   Curated Info

7

Herskowitz JH, et al. (2010) Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration. J Proteome Res 9, 6368-79
20886841   Curated Info

8

Stokes M (2008) CST Curation Set: 3884; Year: 2008; Biosample/Treatment: cell line, Jurkat/pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

9

Ongusaha PP, et al. (2008) Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal 1, ra14
19036714   Curated Info