Thr138
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Home > Phosphorylation Site Page: > Thr138  -  SQSTM1 (human)

Site Information
CNGPVVGtRYkCsVC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 900975704

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 1 ) , 293 (epithelial) ( 1 ) , A549 (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
LRRK2 (human) ( 1 )
Kinases, in vitro:
LRRK2 (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 1 )

References 

1

Kalogeropulou AF, et al. (2018) P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity. Biochem J 475, 1271-1293
29519959   Curated Info

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