Ser9
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Home > Phosphorylation Site Page: > Ser9  -  PSEN2 (human)

Site Information
LTFMAsDsEEEVCDE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449961

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , peptide sequencing ( 2 ) , phosphoamino acid analysis ( 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
brain ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 1 , 2 )

References 

1

Sannerud R, et al. (2016) Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool. Cell 166, 193-208
27293189   Curated Info

2

Walter J, et al. (1996) The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol Med 2, 673-91
8972483   Curated Info