Ser1545

Site Information
RGPQYrAsPPAESMS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 485845

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 )
Disease tissue studied:	breast cancer ( 5 , 8 ) , breast ductal carcinoma ( 5 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 , 5 ) , lung cancer ( 8 ) , non-small cell lung cancer ( 8 ) , melanoma skin cancer ( 3 )
Relevant cell line - cell type - tissue:	breast ( 1 , 5 ) , BT-20 (breast cell) ( 8 ) , H2077 (pulmonary) ( 8 ) , H322M (pulmonary) ( 8 ) , HCC1937 (breast cell) ( 8 ) , HeLa (cervical) ( 4 , 7 , 9 , 10 ) , Jurkat (T lymphocyte) ( 6 ) , K562 (erythroid) ( 7 ) , LOU-NH91 (squamous) ( 8 ) , MCF-7 (breast cell) ( 8 ) , MDA-MB-468 (breast cell) ( 8 ) , NCI-H460 (pulmonary) ( 8 ) , NCI-H520 (squamous) ( 8 ) , PC9 (pulmonary) ( 8 ) , WM239A (melanocyte) ( 3 )

Upstream Regulation
Treatments:	ischemia ( 5 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610 27184836 Curated Info
3	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
4	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
5	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
6	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
7	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
8	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
9	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
10	Cantin GT, et al. (2008) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res 7, 1346-51 18220336 Curated Info