Ser562
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Home > Phosphorylation Site Page: > Ser562  -  GLT1 (mouse)

Site Information
nGksADCsVEEEPWk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486052

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 5 , 6 , 7 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 6 , 7 ) , astrocyte ( 1 ) , brain ( 3 , 4 , 5 ) , liver ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 )
Treatments:
bisindolylmaleimide_II ( 1 ) , Go_6976 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on GLT1:
activity, inhibited ( 1 ) , intracellular localization ( 1 )

References 

1

Wang Y, et al. (2021) Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke. Sci Transl Med 13, eaba3444
34516830   Curated Info

2

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

3

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

4

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

5

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

6

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

7

Munton RP, et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics 6, 283-93
17114649   Curated Info