Ser384
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Home > Phosphorylation Site Page: > Ser384  -  ATP6V1A (mouse)

Site Information
YLGARLAsFYERAGR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 485978

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , [32P] bio-synthetic labeling ( 2 ) , mass spectrometry ( 3 , 4 , 5 , 6 , 7 , 8 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 7 , 8 ) , 'kidney, outer medulla' ( 2 ) , 293 (epithelial) ( 2 ) , brain ( 4 , 5 , 6 ) , kidney ( 5 ) , macrophage-peritoneum ( 3 )

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 2 )
Kinases, in vitro:
AMPKA2 (human) ( 2 )
Treatments:
siRNA ( 2 )

Downstream Regulation
Effects of modification on ATP6V1A:
intracellular localization ( 2 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Alzamora R, et al. (2013) AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol 305, F943-56
23863464   Curated Info

3

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

4

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

6

Wiƛniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

7

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

8

Munton RP, et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics 6, 283-93
17114649   Curated Info