Ser20
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Home > Phosphorylation Site Page: > Ser20  -  Survivin (human)

Site Information
FLkDHRIstFkNWPF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 485776

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 4 ) , mass spectrometry ( 2 ) , mutation of modification site ( 2 , 4 , 5 , 6 ) , phospho-antibody ( 3 , 6 ) , western blotting ( 2 , 3 )
Disease tissue studied:
bone cancer ( 5 ) , ovarian cancer ( 2 ) , prostate cancer ( 2 ) , urethral cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (rat) ( 3 , 6 ) , PLK1 (human) ( 4 , 5 )
Kinases, in vitro:
AurC (human) ( 2 ) , PKACA (human) ( 6 ) , PLK1 (human) ( 4 , 5 )
Phosphatases, in vitro:
PPP2CA (human) ( 6 )
Treatments:
BI2536 ( 5 ) , CGP74514A ( 4 ) , colforsin ( 6 ) , DAP-81 ( 4 ) , H2O2 ( 3 ) , NKH_477 ( 3 ) , peptide inhibitor ( 6 ) , siRNA ( 6 ) , staurosporine ( 6 )

Downstream Regulation
Effects of modification on Survivin:
intracellular localization ( 5 , 6 ) , molecular association, regulation ( 6 ) , phosphorylation ( 4 ) , protein stabilization ( 3 )
Effects of modification on biological processes:
apoptosis, induced ( 6 ) , cell cycle regulation ( 2 , 4 , 5 )
Inhibit interaction with:
XIAP (human) ( 6 )

References 

1

Benaiges E, et al. (2021) Survivin drives tumor-associated macrophage reprogramming: a novel mechanism with potential impact for obesity. Cell Oncol (Dordr)
33710603   Curated Info

2

Sasai K, Katayama H, Hawke DH, Sen S (2016) Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. PLoS One 11, e0157305
27332895   Curated Info

3

Muschol-Steinmetz C, et al. (2013) Function of survivin in trophoblastic cells of the placenta. PLoS One 8, e73337
24069188   Curated Info

4

Chu Y, et al. (2011) Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J Mol Cell Biol 3, 260-7
21148584   Curated Info

5

Colnaghi R, Wheatley SP (2010) Liaisons between survivin and Plk1 during cell division and cell death. J Biol Chem 285, 22592-604
20427271   Curated Info

6

Dohi T, Xia F, Altieri DC (2007) Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell 27, 17-28
17612487   Curated Info