Thr19
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Home > Phosphorylation Site Page: > Thr19  -  MRLC2 (cow)

Site Information
KKRPQRAtsNVFAMF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448596

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
BPAEC ( 1 , 2 , 3 ) , HPAEC (endothelial) ( 3 )

Upstream Regulation
Regulatory protein:
P38A (human) ( 1 )
Putative in vivo kinases:
ROCK1 (human) ( 2 )
Treatments:
Clostridium_toxin_B ( 2 ) , exoenzyme_C3 ( 2 ) , phorbol_ester ( 3 ) , thrombin ( 1 , 2 )

References 

1

Borbiev T, et al. (2004) p38 MAP kinase-dependent regulation of endothelial cell permeability. Am J Physiol Lung Cell Mol Physiol 287, L911-8
15475493   Curated Info

2

Birukova AA, et al. (2004) Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res 67, 64-77
14709404   Curated Info

3

Bogatcheva NV, et al. (2003) Phorbol esters increase MLC phosphorylation and actin remodeling in bovine lung endothelium without increased contraction. Am J Physiol Lung Cell Mol Physiol 285, L415-26
12740219   Curated Info