Tyr1000
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Home > Phosphorylation Site Page: > Tyr1000  -  INSR (rat)

Site Information
YASSNPEyLSASDVF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447685

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
adipocyte-adipose tissue ( 3 ) , liver ( 1 , 2 )

Upstream Regulation
Treatments:
hemorrhage ( 2 ) , insulin ( 1 , 2 , 3 ) , irbesartan ( 1 ) , trauma ( 2 ) , wortmannin ( 3 )

References 

1

Muñoz MC, et al. (2009) TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. J Endocrinol 201, 185-97
19251743   Curated Info

2

Ma Y, et al. (2004) Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha. Endocrinology 145, 5168-76
15297437   Curated Info

3

Hers I, et al. (2002) Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. Biochem J 368, 875-84
12220227   Curated Info