Ser179
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Home > Phosphorylation Site Page: > Ser179  -  syndecan-4 (human)

Site Information
MKkKDEGsyDLGKKP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449863

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
breast cancer ( 1 , 3 )
Relevant cell line - cell type - tissue:
'heart, ventricle' ( 2 ) , 293 (epithelial) ( 2 ) , MCF-7 (breast cell) ( 1 , 3 )

Upstream Regulation
Putative upstream phosphatases:
PPP3CA (human) ( 2 )
Treatments:
aortic banding ( 2 )

Downstream Regulation
Effects of modification on syndecan-4:
activity, inhibited ( 2 ) , intracellular localization ( 3 ) , molecular association, regulation ( 1 , 2 , 4 , 5 ) , phosphorylation ( 2 ) , protein processing ( 3 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell adhesion, altered ( 4 ) , cell cycle regulation ( 3 ) , cytoskeletal reorganization ( 3 , 4 ) , signaling pathway regulation ( 2 )
Induce interaction with:
TIAM1 (human) ( 1 )
Inhibit interaction with:
Calmodulin (human) ( 2 ) , Other ( 4 , 5 ) , PKCA (human) ( 2 ) , PPP3CA (human) ( 2 ) , syndecan-4 (human) ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
hypertrophic cardiomyopathy ( 2 )

References 

1

Keller-Pinter A, et al. (2017) The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction-dependent manner. PLoS One 12, e0187094
29121646   Curated Info

2

Finsen AV, et al. (2011) Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. PLoS One 6, e28302
22164265   Curated Info

3

Keller-Pinter A, et al. (2010) Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner. Cell Mol Life Sci 67, 1881-94
20229236   Curated Info

4

Couchman JR, et al. (2002) Regulation of inositol phospholipid binding and signaling through syndecan-4. J Biol Chem 277, 49296-303
12377772   Curated Info

5

Horowitz A, Simons M (1998) Phosphorylation of the cytoplasmic tail of syndecan-4 regulates activation of protein kinase Calpha. J Biol Chem 273, 25548-51
9748216   Curated Info