Ser1291

Site Information
EsVEGFLsPsRCGSR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 483697

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 )
Relevant cell line - cell type - tissue:	'brain, cerebellum' ( 11 ) , 'brain, cerebral cortex' ( 11 , 12 ) , 'brain, forebrain' ( 10 ) , 'brain, hippocampus, dentate gyrus' ( 11 ) , 'brain, midbrain' ( 11 ) , 'fat, brown' ( 8 ) , brain ( 4 , 5 , 8 , 9 , 13 ) , HL-1 (myocyte) ( 1 ) , kidney ( 8 ) , lung ( 8 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 7 ) , PC-12 (chromaffin) [TrkA (rat), transfection] ( 6 ) , PC-12 (chromaffin) ( 6 ) , spleen ( 8 )

In vivo Characterization

Methods used to characterize site in vivo:

mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 )

Relevant cell line - cell type - tissue:

'brain, cerebellum' ( 11 ) , 'brain, cerebral cortex' ( 11 , 12 ) , 'brain, forebrain' ( 10 ) , 'brain, hippocampus, dentate gyrus' ( 11 ) , 'brain, midbrain' ( 11 ) , 'fat, brown' ( 8 ) , brain ( 4 , 5 , 8 , 9 , 13 ) , HL-1 (myocyte) ( 1 ) , kidney ( 8 ) , lung ( 8 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 7 ) , PC-12 (chromaffin) [TrkA (rat), transfection] ( 6 ) , PC-12 (chromaffin) ( 6 ) , spleen ( 8 )

Upstream Regulation
Treatments:	PDGF ( 6 )

References
1	Reinartz M, Raupach A, Kaisers W, Gödecke A (2014) AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes. J Proteome Res 13, 4232-45 25162660 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51 22942356 Curated Info
4	Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29 22645316 Curated Info
5	Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9 22807455 Curated Info
6	Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA (2012) The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics 11, 15-30 22027198 Curated Info
7	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
8	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
9	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
10	Collins MO, et al. (2008) Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder. Mol Cell Proteomics 7, 1331-48 18388127 Curated Info
11	Trinidad JC, et al. (2008) Quantitative analysis of synaptic phosphorylation and protein expression. Mol Cell Proteomics 7, 684-96 18056256 Curated Info
12	Munton RP, et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics 6, 283-93 17114649 Curated Info
13	Trinidad JC, et al. (2006) Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics 5, 914-22 16452087 Curated Info