Ser10
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Home > Phosphorylation Site Page: > Ser10  -  SYN2 (mouse)

Site Information
NFLRRRLsDSSFIAN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449839

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 2 ) , mass spectrometry ( 2 ) , microscopy-colocalization with upstream kinase ( 4 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 , 4 ) , western blotting ( 2 , 4 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 2 ) , 3T3-L1 (fibroblast) ( 3 ) , epithelial-lens ( 4 )

Upstream Regulation
Treatments:
insulin ( 3 )

Downstream Regulation
Effects of modification on SYN2:
intracellular localization ( 3 )

References 

1

Qin Z, et al. (2013) Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent. PLoS One 8, e80758
24224061   Curated Info

2

John JP, Chen WQ, Pollak A, Lubec G (2007) Mass spectrometric studies on mouse hippocampal synapsins Ia, IIa, and IIb and identification of a novel phosphorylation site at serine-546. J Proteome Res 6, 2695-710
17579389   Curated Info

3

Muretta JM, Romenskaia I, Cassiday PA, Mastick CC (2007) Expression of a synapsin IIb site 1 phosphorylation mutant in 3T3-L1 adipocytes inhibits basal intracellular retention of Glut4. J Cell Sci 120, 1168-77
17341582   Curated Info

4

Frederikse PH, et al. (2004) Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Mol Vis 10, 794-804
15529118   Curated Info