Ser15
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser15  -  PYGM (human)

Site Information
QEKrKQIsVRGLAGV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449838
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:
lung cancer ( 1 , 2 , 4 , 6 ) , non-small cell lung cancer ( 1 , 6 ) , non-small cell lung adenocarcinoma ( 1 , 2 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 5 ) , A549 (pulmonary) ( 1 ) , CL1-0 (pulmonary) ( 4 ) , CL1-1 (pulmonary) ( 4 ) , CL1-2 (pulmonary) ( 4 ) , CL1-5 (pulmonary) ( 4 ) , HT-29 (intestinal) ( 7 ) , HUES-9 ('stem, embryonic') ( 3 ) , lung ( 1 , 2 ) , NCI-H1299 (pulmonary) ( 6 ) , NCI-H1355 (pulmonary) ( 1 ) , NCI-H1792 (pulmonary) ( 1 ) , NCI-H23 (pulmonary) ( 1 ) , NCI-H441 (pulmonary) ( 1 )

Upstream Regulation
Treatments:
metastatic potential ( 4 )

Downstream Regulation
Effects of modification on PYGM:
enzymatic activity, induced ( 8 ) , protein conformation ( 8 )

References 

1

Rikova K, Hall B (2013) CST Curation Set: 20736, 21163, 30158, 30159, 30160; Year: 2013; Biosample/Treatment: cell line, A549, H1355, H23, H441, H1792; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

2

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

3

Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3
21406692   Curated Info

4

Wang YT, et al. (2010) An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion. J Proteome Res 9, 5582-97
20815410   Curated Info

5

Højlund K, et al. (2009) In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS. J Proteome Res 8, 4954-65
19764811   Curated Info

6

Tsai CF, et al. (2008) Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics. J Proteome Res 7, 4058-69
18707149   Curated Info

7

Kim JE, Tannenbaum SR, White FM (2005) Global phosphoproteome of HT-29 human colon adenocarcinoma cells. J Proteome Res 4, 1339-46
16083285   Curated Info

8

Carty TJ, Tu J-I, Graves DJ (1975) Regulation of glycogen phosphorylase. Role of the peptide region surrounding the phosphoserine residue in determining enzyme properties. J Biol Chem 250, 4980-5
1150650   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.