Tyr277
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Home > Phosphorylation Site Page: > Tyr277  -  LATS1 (mouse)

Site Information
PSSQTKRySGNMEYV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 484657

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 )

Upstream Regulation
Regulatory protein:
JAK1 (human) ( 1 )
Putative in vivo kinases:
Tyk2 (human) ( 1 )
Kinases, in vitro:
Tyk2 (human) ( 1 )
Treatments:
IFN-alpha ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on LATS1:
enzymatic activity, induced ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
cell growth, inhibited ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )

References 

1

Zuo Y, et al. (2022) LATS1 is a central signal transmitter for achieving full type-I interferon activity. Sci Adv 8, eabj3887
35394840   Curated Info

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