Thr680

Site Information
IEDsREAtHSsGFSG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 484623

In vivo Characterization
Methods used to characterize site in vivo:	immunoassay ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 1 , 2 )

Downstream Regulation
Effects of modification on BUB1B:	intracellular localization ( 1 ) , molecular association, regulation ( 1 , 2 ) , phosphorylation ( 1 )
Effects of modification on biological processes:	cell cycle regulation ( 1 , 2 )
Induce interaction with:	PPP2CA (human) ( 1 ) , PPP2R5A (human) ( 2 )

References
1	Corno A, et al. (2023) A bifunctional kinase-phosphatase module balances mitotic checkpoint strength and kinetochore-microtubule attachment stability. EMBO J, e112630 37712330 Curated Info
2	Suijkerbuijk SJ, Vleugel M, Teixeira A, Kops GJ (2012) Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments. Dev Cell 23, 745-55 23079597 Curated Info